一文了解抗生素的精神副作用「临床必备 」
克拉霉素、β-内酰胺类和氟喹诺酮类药物因其GABA-A拮抗作用而对中枢神经系统产生影响。具有剂量依赖活性的药物包括:利奈唑胺,它可以通过其单胺氧化物(MAO)抑制剂活性表现出CNS活性;甲硝唑,在累积或超治疗水平时可引起神经精神效应;四环素类药物,这类药物更可能对CYP2C19活性降低的患者造成中枢神经系统的影响。
1、β-内酰胺类
2、甲硝唑
3、大环内酯类
4、氟喹诺酮类
5、恶唑烷酮类
6、硝基呋喃类
7、磺胺类药
8、四环素
结论
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